Lusine Zakaryan, born Svetlana Zakaryan (June 1, 1937 – December 30, 1991), was an Armenian soprano.

From 1970 to 1983, Zakaryan was a soloist with the symphony orchestra of Armenian TV and Radio. She also sang in the choir of the Armenian Apostolic Church’s Holy See at the Echmiadzin Cathedral, and it is for her magnificent rendition of centuries-old Armenian spiritual hymns that she is now most remembered for.